Symantec recommends that you perform consistency checks before running an offhost backup.
See Backing up Exchange.
If the Advanced Disk-based Backup Option (ADBO) is installed on the media server, you can use the Backup Exec Granular Recovery Technology (GRT) option when you create an offhost backup for the Information Store. You can restore individual mailboxes, mail messages, and public folders from Information Store backups for which GRT is enabled.
See Configuring a GRT-enabled offhost backup for Exchange resources.
To configure an offhost backup with the Exchange Agent
Create an Exchange backup job.
See Backing up Exchange.
In the Properties pane, under Settings, click Advanced Disk-based Option.
Ensure that the snapshot provider that you select is Automatic - Use hardware if available; otherwise use software.
If resources that are not supported for offhost backup are included in the backup selection list, check Process logical volumes for offhost backup one at a time to allow the job to complete with errors.
More Information
How to restore individual items by using Granular Recovery Technology