HKLM\SOFTWARE\
The Microsoft subkey stores configuration data for Microsoft programs running on the computer. The subkeys in the Microsoft subkey represent each of the programs and store settings that only affect the program.
The Microsoft subkey in HKEY_LOCAL_MACHINE stores entries that apply to all users of the computer. There is also a Software\Microsoft subkey in HKEY_CURRENT_USER that stores entries that apply only to the current user of the computer.
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